5-Amino-1MQ

5-Amino-1MQ – NNMT Inhibitor

At a Glance: 5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic, membrane-permeable small molecule. Note: While frequently grouped with peptides in research catalogs, it is structurally a quinoline derivative small molecule. What it is used for: It is utilized in advanced laboratory research to study extreme fat loss, metabolic syndrome reversal, and cellular anti-aging. In lab rat models, researchers study its ability to block the NNMT enzyme, effectively forcing the animal's metabolism into a high-energy, fat-burning state without suppressing appetite or altering muscle mass.

Product Overview

5-Amino-1MQ is a highly selective inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme heavily involved in cellular metabolism and energy storage. As lab rats age or develop obesity, NNMT expression drastically increases in white adipose (fat) tissue, which drives NAD+ depletion and violently slows down the metabolic rate. By selectively blocking this enzyme, 5-Amino-1MQ preserves cellular NAD+ levels and massively upregulates energy expenditure. This makes it a pivotal compound for researching diet-induced obesity, allowing researchers to observe significant reductions in fat mass and enhanced muscle stem cell regeneration in animal models independent of dietary restrictions.

Technical Specifications

• Molecular Formula: C10H11N2+ (Base cation) / C10H11IN2 (often synthesized as an Iodide salt)

• Molecular Weight: 159.21 g/mol (Cation base) / 286.11 g/mol (Iodide salt)

• CAS Number: 42464-96-0

• Chemical Profile: 5-amino-1-methylquinolinium (Selective NNMT Inhibitor)

Mechanism of Action

5-Amino-1MQ initiates profound systemic metabolic shifts by targeting a single enzymatic pathway:

• Targeted NNMT Inhibition: Strongly binds to and inhibits the NNMT enzyme, preventing it from excessively consuming S-adenosyl methionine (SAM) and nicotinamide (NAM).

• NAD+ Preservation: By blocking the NNMT "drain," it directly preserves and increases intracellular NAD+ levels, which are critical for mitochondrial function, ATP production, and the activation of longevity-associated sirtuins (specifically SIRT1).

• Metabolic Reprogramming: The downstream effect is a drastic increase in basal metabolic rate and lipolysis (fat breakdown) within white adipose cells. It effectively shrinks fat cell size and clears hepatic lipid deposits in lab rats, while simultaneously enhancing myoblast differentiation to repair aged or damaged skeletal muscle.

🚚 📦 Availability 

At CNL, we believe quality is worth the wait. Instead of stocking products and have them sit for months, most orders are produced in small batches to maintain the quality and consistency our customers expect.

Production typically takes approximately two weeks. While this isn't the norm in today's world of overnight delivery, it's how we deliver the premium quality we're known for.

Limited inventory may be available for immediate shipment after large production runs or special promotions.

As a thank you for your patience, we offer bundle discounts of up to 50% OFF.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. 5-Amino-1MQ is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.