HUGE FOURTH OF JULY SALE!! Up to 30% OFF on all products, email or submit a contacts form for pricing or to purchase!

ACE-031

ACE-031 (Myostatin Inhibitory Peptide 7) – ActRIIB Fragment

At a Glance: ACE-031, often synthesized as Myostatin Inhibitory Peptide 7, is a targeted research peptide engineered to inhibit myostatin, a naturally occurring protein that restricts muscle growth. What it is used for: It is utilized in advanced laboratory research to study extreme muscle hypertrophy, bone metabolism, and the prevention of muscle wasting (atrophy). By neutralizing myostatin and related ligands, it allows for unregulated muscle fiber expansion in lab rat models.

Product Overview

ACE-031 is a potent research compound designed to mimic the binding mechanisms of the Activin Receptor Type IIB (ActRIIB). Myostatin is a member of the TGF-β superfamily of proteins that acts as a negative biological regulator—essentially signaling the body to stop building muscle. By acting as a decoy or binding agent, this peptide captures myostatin and related inhibitory proteins (like Activin A) before they can bind to native cellular receptors. This effectively removes the biological brakes on muscle growth, promoting significant hypertrophy and strength gains in research subjects.

Technical Specifications

  • Molecular Formula: C133H227N43O33

  • Molecular Weight: 2956.5 g/mol

    PubChem - NIH

  • CAS Number: 1621169-52-5

Sequence Profile: Ala-Trp-Arg-Gln-Asn-Thr-Arg-Tyr-Ser-Arg-Ile-Glu-Ala-Ile-Lys-Ile-Gln-Ile-Leu-Ser-Lys-Leu-Arg-Leu-NH2 (24-amino acid sequence)

Mechanism of Action

ACE-031 acts as a highly specialized decoy and neutralizing agent within the TGF-β signaling pathway:

  • Myostatin Neutralization: Strongly binds to circulating myostatin (GDF-8), preventing it from attaching to the natural ActRIIB receptors on the surface of muscle cells.

    Analytical Science Journals - Wiley

  • Activin A Inhibition: Binds to and neutralizes Activin A and other related ligands that also negatively regulate muscle mass and bone density.

  • Intracellular Pathway Blockade: By intercepting these ligands, it prevents the phosphorylation and activation of Smad2/3 intracellular signaling proteins. The downstream effect is a profound increase in protein synthesis and muscle cell differentiation, leading to unregulated skeletal muscle hypertrophy independent of mechanical stimulus.

Primary Research Applications

ACE-031 is a vital compound for in vitro and lab rat model studies focusing on:

  • Severe muscular dystrophies (e.g., Duchenne Muscular Dystrophy) and age-related sarcopenia

    Analytical Science Journals - Wiley

  • Motor neuron diseases such as Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA)

    ResearchGate

  • Disuse atrophy models (e.g., spaceflight, prolonged bed rest, or immobilization)

  • Bone density and osteogenesis pathways directly linked to muscle-bone crosstalk

Storage & Handling

For optimal stability and structural integrity, store lyophilized powder at -4°F (-20°C). Once reconstituted, store at 36°F to 46°F (2°C to 8°C) and strictly protect from light.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. ACE-031 is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.