HUGE FOURTH OF JULY SALE!! Up to 30% OFF on all products, email or submit a contacts form for pricing or to purchase!

AHK-Cu

AHK-Cu (Copper Tripeptide-3)

At a Glance: AHK-Cu is a synthetic, copper-binding tripeptide composed of the amino acids alanine, histidine, and lysine. What it is used for: It is utilized in advanced laboratory research to study extracellular matrix remodeling, dermal cell proliferation, and angiogenesis. By delivering targeted copper ions, it is heavily studied in lab rat models for its unique capacity to stimulate hair follicle elongation and accelerate cutaneous tissue repair.

Product Overview

AHK-Cu (Alanine-Histidine-Lysine-Copper) is a specialized bioactive peptide related to the well-known GHK-Cu, but uniquely distinguished by the substitution of alanine for glycine. This specific amino acid sequence alters its biological affinity, making it particularly effective at interacting with dermal papilla cells (DPCs) and fibroblasts. AHK-Cu acts as a sophisticated delivery vehicle, binding to circulating copper ions and transporting them directly into target cells to stimulate enzymatic activity, promote collagen synthesis, and enhance local vascularization in research subjects.

Technical Specifications

  • Molecular Formula: C15H24CuN6O4

  • Molecular Weight: 415.93 g/mol

    AbMole 

  • CAS Number: 682809-81-0 / 767286-83-9

  • Sequence Profile: Ala-His-Lys-Cu

Mechanism of Action

AHK-Cu functions by modulating cellular activity at the dermal and follicular levels:

  • Targeted Copper Delivery: Forms a highly stable complex with copper(II) ions, facilitating their transport into cells where they activate critical metalloproteinases and cellular enzymes.

  • Fibroblast & DPC Proliferation: Directly stimulates the proliferation of dermal fibroblasts and dermal papilla cells, which are fundamental to the morphogenesis and elongation of hair follicles.

  • Apoptosis Preclusion: Modulates intracellular signaling pathways to delay or reduce the programmed cell death (apoptosis) of follicular cells, theoretically extending the active growth phase (anagen) of the hair cycle.

  • Extracellular Matrix Remodeling: Upregulates the production of Type I and Type III collagen while stimulating the secretion of vascular endothelial growth factor (VEGF) to improve microcirculation at the application site.

Primary Research Applications

AHK-Cu is a vital compound for in vitro and lab rat model studies focusing on:

  • Hair follicle elongation and cellular proliferation pathways

  • Dermal papilla cell (DPC) viability and anagen phase extension

  • Advanced wound healing and cutaneous tissue repair

  • Skin elasticity, anti-inflammatory responses, and extracellular matrix remodeling

    BOC Sciences Amino Acid

Storage & Handling

For optimal stability and structural integrity, store the lyophilized powder at -4°F (-20°C). Once reconstituted, store at 36°F to 46°F (2°C to 8°C), sealed tightly, and strictly protect from moisture and light.

⚠️ Important Disclaimer: All information provided is for educational and reference purposes only. AHK-Cu is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.