AOD-9604 (HGH Fragment 176-191)

Product Overview

AOD-9604 is a highly specialized, synthetic 16-amino acid peptide corresponding to the C-terminal region (amino acids 176-191) of human Growth Hormone (hGH). It was meticulously engineered to isolate the profound lipolytic (fat-burning) activity of natural growth hormone while completely eliminating its growth-promoting and diabetogenic effects. This makes AOD-9604 an exceptional research compound for investigating targeted fat metabolism, visceral adipose reduction, and advanced cartilage regeneration without the confounding variables of systemic IGF-1 elevation or insulin resistance.

Technical Specifications

• Molecular Formula: C78H123N23O23S2

• Molecular Weight: 1815.08 g/mol

• CAS Number: 221231-10-3

• Sequence Profile: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (Modified hGH fragment isolating the lipolytic domain)

Mechanism of Action

AOD-9604 uniquely bypasses the growth hormone receptor (GHR) to exert its metabolic and regenerative effects through distinct pathways:

• Beta-3 Adrenergic Receptor Activation: Interacts directly with beta-3 adrenergic receptors on adipocytes, triggering hormone-sensitive lipase activation. This potently stimulates lipolysis (the breakdown of fat) and inhibits lipogenesis (the formation of new fat).

• Metabolic Selectivity: Because it lacks the N-terminal GHR binding domain of full-length hGH, AOD-9604 does not stimulate IGF-1 production, induce tissue growth, or negatively impact fasting glucose and insulin sensitivity.

• Chondroprotection & Cartilage Repair: Independent of its fat-metabolizing actions, it promotes chondrocyte proteoglycan synthesis (including type II collagen and aggrecan) and reduces the activity of matrix metalloproteinases (MMPs) that degrade healthy cartilage.

Primary Research Applications

AOD-9604 is a premier compound for in vitro and animal model studies investigating:

• Targeted Adipose Tissue Reduction and Lipolysis Enhancement

• Visceral Fat Mobilization and Metabolic Syndrome Interventions

• Cartilage Regeneration and Osteoarthritis Repair Models

• Non-Hormonal Obesity Treatments (without IGF-1 or glycemic interference)

• Bone Metabolism and Osteoblast Activity Optimization

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C). Reconstituted solutions should be kept refrigerated at 36°F to 46°F (2°C to 8°C) to preserve the peptide sequence.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. AOD-9604 is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.