BPC-157 (Body Protection Compound) – Pentadecapeptide

Product Overview

BPC-157 is a highly advanced, synthetic 15-amino acid peptide derived from a naturally occurring protective protein found in human gastric juice. Uniquely characterized by its remarkable stability in harsh acidic environments, it is one of the very few peptides capable of maintaining structural integrity for oral bioavailability in preclinical models. BPC-157 is widely utilized in regenerative research for its unparalleled ability to accelerate tissue repair, promote organized angiogenesis, and protect against cellular damage across a broad spectrum of physiological systems.

Technical Specifications

• Molecular Formula: C62H98N16O22

• Molecular Weight: 1419.53 g/mol

• CAS Number: 137525-51-0

• Sequence Profile: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (Original acetate form or stabilized arginine salt form depending on synthesis protocol)

Mechanism of Action

BPC-157 operates through a unique "hit-and-run" pharmacological mechanism—often referred to as the Gene Expression Paradox—where its rapid systemic clearance initiates a long-lasting, permanent healing cascade:

• Organized Angiogenesis (Egr-1/NAB2 Loop): Acts as a master thermostat for blood vessel formation. It activates the Egr-1 gene to stimulate new vessel growth while simultaneously triggering NAB2 as an internal brake, preventing the chaotic, excessive leaky vessel growth seen with standard angiogenic factors like VEGF alone.

• Nitric Oxide (NO) System Modulation: Unlocks the NO enzyme (via Src-Caveolin-1 phosphorylation) to regulate blood flow to injury sites. It acts homeostatically, boosting NO when low or stepping in to lower NO levels if they become dangerously high.

• Fibroblast & Growth Hormone Receptor Upregulation: Rapidly triggers a burst of gene expression, significantly increasing Growth Hormone Receptor (GHR) density in tendon fibroblasts to accelerate collagen synthesis and structural remodeling.

Primary Research Applications

BPC-157 is a premier compound for in vitro and animal model studies investigating:

• Musculoskeletal Regeneration (Tendon tears, ligament damage, muscle crush injuries, and bone fractures)

• Gastrointestinal Protection and Cytoprotection (NSAID-induced lesions, ulcers, and IBD/leaky gut models)

• Accelerated Wound Healing and Burn Recovery Optimization

• Neuroprotection (Peripheral nerve regeneration, TBI models, and dopaminergic system modulation)

• Organoprotection (Hepatoprotective, renal, and cardiac ischemia-reperfusion models)

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C). Reconstituted solutions should be kept refrigerated at 36°F to 46°F (2°C to 8°C) and utilized within 4-6 weeks to preserve the peptide sequence.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. BPC-157 is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.