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CJC-1295 NO DAC

CJC-1295 No DAC (Modified GRF 1-29) – GHRH Analogue

At a Glance: CJC-1295 No DAC (most accurately referred to as Modified GRF 1-29) is a synthetic, 29-amino acid peptide analogue of naturally occurring Growth Hormone-Releasing Hormone (GHRH). What it is used for: It is utilized in advanced laboratory research to study the natural, pulsatile release of growth hormone. In lab rat models, researchers study its ability to stimulate the pituitary gland to enhance cellular repair, muscle growth, and fat metabolism without causing the unnatural "bleed" of constantly elevated growth hormone levels.

Product Overview

CJC-1295 No DAC is a highly targeted research peptide designed to precisely mimic the biological action of endogenous GHRH. The "No DAC" (Drug Affinity Complex) designation is crucial: it means this specific molecule lacks the bioconjugation complex that extends a peptide's half-life to several days. Instead, it maintains a short, highly effective biological half-life of approximately 30 minutes. This allows researchers to induce sharp, natural pulses of growth hormone in animal subjects, cleanly simulating youthful metabolic function. In research settings, it is frequently studied in combination with a Growth Hormone Secretagogue (such as Ipamorelin) to observe the synergistic amplification of these natural GH pulses.

Technical Specifications

  • Molecular Formula: C152H252N44O42

  • Molecular Weight: 3367.97 g/mol

  • CAS Number: 863288-34-0

  • Sequence Profile: Tyr-d-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 (Tetrasubstituted growth hormone-releasing factor 1-29)

Mechanism of Action

CJC-1295 No DAC initiates profound regenerative effects by targeting the apex of the growth hormone cascade:

  • GHRH Receptor Agonism: Binds directly and with high affinity to the growth hormone-releasing hormone receptor (GHRHR) located on the somatotroph cells of the anterior pituitary gland.

  • Pulsatile GH Secretion: Triggers a rapid, physiological pulse of growth hormone into the bloodstream. Because it is quickly cleared from the system (due to the lack of DAC), it strictly respects the lab rat's natural circadian rhythms, allowing GH levels to rise and fall organically.

  • Hepatic IGF-1 Elevation: The transient surge of growth hormone subsequently signals the liver to increase the production of Insulin-like Growth Factor 1 (IGF-1), which is the primary biological driver of deep tissue repair, muscle protein synthesis, and cellular regeneration.

  • Deep Sleep Modulation: By mimicking natural GHRH pulses, it actively promotes the onset and duration of slow-wave (deep) sleep in animal models, the exact physiological window where maximum physical recovery occurs.

Primary Research Applications

CJC-1295 No DAC is a vital compound for in vitro and animal model studies focusing on:

  • Somatopause and the reversal of age-related growth hormone decline

  • Enhanced lipolysis (fat breakdown) and metabolic rate optimization

  • Skeletal muscle hyperplasia, hypertrophy, and connective tissue repair in active lab rats

  • Slow-wave sleep architecture and CNS recovery pathways

Storage & Handling

For optimal stability and structural integrity, store the lyophilized powder at -4°F (-20°C). Once reconstituted, store at 36°F to 46°F (2°C to 8°C), sealed tightly, and strictly protect from moisture and light.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. CJC-1295 No DAC is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.