Epithalon (Telomerase Activator Peptide) – Epitalon / AGAG

Product Overview

Epithalon is a synthetic, specialized tetrapeptide explicitly modeled on the natural polypeptide Epithalamin, an endogenous extract produced by the pineal gland. Initially developed at the St. Petersburg Institute of Bioregulation and Gerontology, it is considered a breakthrough compound in the biology of aging. Epithalon is a premier research material utilized in advanced cellular longevity studies to investigate the epigenetic activation of telomerase, the extension of replicative lifespan in human somatic cells, and the neuroendocrine restoration of circadian rhythms.

Technical Specifications

• Molecular Formula: C14H22N4O9

• Molecular Weight: 390.35 g/mol

• CAS Number: 307297-39-8

• Sequence Profile: Ala-Glu-Asp-Gly (Synthetically isolated active sequence corresponding to native pineal gland secretions)

Mechanism of Action

Epithalon exerts its profound anti-aging and cellular rejuvenation effects through highly specific epigenetic and neuroendocrine pathways:

• Epigenetic Telomerase Activation: Epithalon uniquely modifies chromatin accessibility at the TERT gene promoter via histone acetylation changes. This epigenetic remodeling increases the expression of telomerase reverse transcriptase, enabling the addition of telomeric DNA to chromosome ends and actively preserving telomere length.

• Overcoming the Hayflick Limit: By elongating telomeres in senescing human somatic cells (like fibroblasts), Epithalon allows these cells to safely divide and function beyond their normal, programmed replicative threshold.

• Pinealocyte & Melatonin Normalization: Restores pineal gland function by reducing age-related lipofuscin accumulation and normalizing gene expression. This effectively re-establishes nocturnal melatonin secretion back toward youthful levels, rescuing disrupted circadian rhythms.

• Cellular Antioxidant & Immune Defense: Upregulates endogenous antioxidant enzyme systems (SOD, catalase, glutathione peroxidase) to drastically reduce reactive oxygen species (ROS). Furthermore, it counteracts immunosenescence by restoring thymic hormone production and enhancing T-lymphocyte surveillance.

Primary Research Applications

Epithalon is a crucial compound for in vitro and animal model studies investigating:

• Telomere Elongation, hTERT Expression, and Cellular Senescence Reversal

• Maximum Lifespan Extension and Geroprotective Strategies

• Pineal Gland Involution and Age-Related Circadian Rhythm Disruption

• Immunosenescence and Thymic Involution Recovery

• Endogenous Antioxidant Upregulation and Oxidative Stress Mitigation

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C). Reconstituted solutions should be kept refrigerated at 36°F to 46°F (2°C to 8°C) and utilized promptly, avoiding any repeated freeze-thaw cycles.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. Epithalon is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.