GHK-Cu (Copper Peptide Complex) – Copper Tripeptide-1

Product Overview

GHK-Cu is a naturally occurring, high-affinity copper-chelating tripeptide originally isolated from human plasma. Acting as a master regulator of tissue remodeling and extracellular matrix organization, this remarkable compound naturally declines with age. GHK-Cu is engineered to deliver essential copper ions directly into cellular pathways, serving as a premier research compound for investigations into broad-spectrum gene expression modulation, robust collagen synthesis, and advanced dermatological repair.

Technical Specifications

• Molecular Formula: C14H23CuN6O4

• Molecular Weight: 340.38 g/mol (without copper); complexed weight varies slightly

• CAS Number: 49557-75-7 (GHK) / 89030-95-5 (GHK-Cu Complex)

• Sequence Profile: Gly-His-Lys complexed with Cu²⁺ (A stable 1:1 complex ensuring targeted copper delivery)

Mechanism of Action

GHK-Cu achieves its profound regenerative effects through multiple systemic and cellular pathways, highly dependent on its essential copper ion:

• Broad Gene Expression Modulation: Acts as a master reset switch, upregulating over 4,000 genes associated with healthy tissue function, DNA repair, and antioxidant defense, while suppressing genes linked to cellular senescence and tissue destruction.

• Extracellular Matrix Remodeling: Strongly stimulates the production of collagen (Types I, III, and IV), elastin, decorin, and glycosaminoglycans, while optimizing the balance between tissue-building TIMPs and damaged-protein-clearing MMPs.

• Antioxidant & Anti-Inflammatory Activation: Directly supplies the critical copper necessary for the function of superoxide dismutase (SOD) and catalase, drastically neutralizing reactive oxygen species (ROS) and suppressing pro-inflammatory cytokines like IL-6, TNF-alpha, and IL-1 beta.

• Angiogenesis & Tissue Regeneration: Accelerates all phases of wound repair, enhancing blood vessel formation, keratinocyte migration, and nerve regeneration.

Primary Research Applications

GHK-Cu is a crucial compound for in vitro and animal model studies investigating:

• Advanced Wound Healing, Scar Revision, and Tissue Remodeling

• Skin Rejuvenation, Collagen Density, and Photoaging Reversal

• Hair Follicle Enlargement and Anagen Phase Extension

• Systemic Anti-Inflammatory and Antioxidant Gene Activation

• Neuroprotection and Nerve Growth Factor (NGF) Stimulation

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C). Reconstituted solutions should be kept refrigerated at 36°F to 46°F (2°C to 8°C) and protected from light.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. GHK-Cu is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.