GHRP-2 (Growth Hormone Secretagogue) – Pralmorelin / KP-102

Product Overview

GHRP-2 is a highly potent, synthetic hexapeptide growth hormone secretagogue (GHRP). Recognized for its robust efficacy, it is considered one of the most potent GH-releasing peptides on a per-microgram basis. It offers a balanced, optimized profile by providing massive GH stimulation with significantly less appetite stimulation than GHRP-6 and less cortisol elevation than Hexarelin. Uniquely, GHRP-2 has achieved formal clinical validation as an approved diagnostic agent in certain countries for assessing pituitary GH reserve, making it a premier compound for advanced endocrinology, somatopause, and body composition research.

Technical Specifications

• Molecular Formula: C45H55N9O6

• Molecular Weight: 817.97 g/mol

• CAS Number: 158861-67-7

• Sequence Profile: D-Ala-D-βNal-Ala-Trp-D-Phe-Lys-NH2

Mechanism of Action

GHRP-2 drives its powerful neuroendocrine effects through highly targeted receptor activation and downstream anabolic signaling:

• GHSR-1a Agonism: Binds with high affinity to the ghrelin receptor (GHSR-1a) on pituitary somatotroph cells, triggering an intense, rapid, and dose-dependent pulsatile release of growth hormone.

• Downstream IGF-1 Elevation: The robust GH pulse drives subsequent hepatic production of Insulin-like Growth Factor 1 (IGF-1), establishing an elevated plateau that mediates profound anabolic effects, including enhanced protein synthesis and nitrogen retention.

• Balanced Receptor Selectivity: Provides significant GH release while minimizing off-target hormonal effects. It triggers far less ghrelin-mimetic (appetite-stimulating) signaling than GHRP-6 and limits the rapid tachyphylaxis (desensitization) and cortisol spikes associated with Hexarelin.

• Synergistic Amplification: When co-administered with a GHRH analog (such as CJC-1295 or Sermorelin), it activates complementary pituitary pathways, overcoming negative feedback inhibition to yield exponentially greater GH release than either compound alone.

Primary Research Applications

GHRP-2 is a critical compound for in vitro and animal model studies investigating:

• Potent, Acute Growth Hormone Stimulation and Pituitary Reserve Diagnostics

• Sustained IGF-1 Elevation, Nitrogen Retention, and Muscle Protein Synthesis

• Body Composition Optimization and Visceral Adipose Tissue Reduction

• Age-Related Somatopause and Hormone Decline Models

• Endocrine Studies Requiring Minimized Appetite Confounders

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C). Reconstituted solutions should be kept refrigerated at 36°F to 46°F (2°C to 8°C) and utilized promptly in accordance with established laboratory protocols.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. GHRP-2 is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.