GHRP-6 (Growth Hormone Secretagogue) – Growth Hormone Releasing Hexapeptide

Product Overview

GHRP-6 is a highly active, synthetic hexapeptide and a powerful agonist of the ghrelin receptor (GHSR-1a). As a foundational compound in the development of synthetic growth hormone secretagogues, it is widely utilized in endocrine research. GHRP-6 is uniquely recognized for its dual-action profile: producing robust, pulsatile growth hormone (GH) release alongside near-universal, profound appetite stimulation. This makes it an indispensable research material for investigations into the gut-brain axis, extreme feeding behaviors, cachexia models, and gastrointestinal motility.

Technical Specifications

• Molecular Formula: C46H56N12O6

• Molecular Weight: 873.01 g/mol

• CAS Number: 87616-84-0

• Sequence Profile: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (Synthetic met-enkephalin analog engineered for potent ghrelin receptor activation)

Mechanism of Action

GHRP-6 drives its intense physiological effects through targeted receptor activation across multiple biological systems:

• GHSR-1a Agonism (Pituitary): Binds directly to the ghrelin receptor on pituitary somatotrophs, bypassing normal inhibitory feedback to trigger a rapid and massive pulsatile release of GH, driving subsequent downstream IGF-1 production.

• Hypothalamic Appetite Stimulation: Exhibits unparalleled ghrelin-mimetic activity by activating the arcuate nucleus. This triggers the aggressive release of orexigenic (appetite-stimulating) neuropeptides, specifically NPY and AgRP, causing intense and immediate hunger signaling.

• Gastric Motility Modulation: Activates ghrelin receptors within the enteric nervous system and gastrointestinal tract to significantly accelerate gastric emptying time, stimulate the migrating motor complex (MMC), and enhance overall intestinal peristalsis.

• Synergistic Endocrine Amplification: Functions through receptor pathways completely independent of growth hormone-releasing hormone (GHRH). This allows for synergistic, supra-additive amplification of GH pulses when researched concurrently with GHRH analogs (such as CJC-1295).

Primary Research Applications

GHRP-6 is a premier compound for in vitro and animal model studies investigating:

• Intense Appetite Regulation, Feeding Behaviors, and Cachexia Models

• Acute Growth Hormone and IGF-1 Endocrine Axis Stimulation

• Gastrointestinal Motility, Gastroparesis, and Post-Operative Ileus

• Cardioprotective Signaling (PI3K/Akt pathway activation in ischemia-reperfusion models)

• GHRH/GHRP Synergistic Stacking Protocols

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C). Reconstituted solutions should be kept strictly refrigerated at 36°F to 46°F (2°C to 8°C) and utilized promptly in accordance with established laboratory protocols.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. GHRP-6 is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.