GLP-2 TIRZ
$49.99
Tirzepatide (GLP-1/GIP Receptor Agonist) – LY3298176
Product Overview
Tirzepatide is a first-in-class, dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Engineered from the native GIP peptide backbone, it represents a significant structural advancement in metabolic research compounds. By simultaneously activating two critical incretin pathways, Tirzepatide is utilized in advanced studies to observe synergistic effects on glycemic control, energy expenditure, and lipid metabolism.
Technical Specifications
Molecular Formula: C225H348N48O68
Molecular Weight: 4813.45 g/mol
CAS Number: 2023788-19-2
Sequence Profile: 39-amino acid peptide featuring a C20 fatty diacid moiety attached via a glutamic acid spacer, with Aib substitutions for enzymatic resistance.
Mechanism of Action
Tirzepatide is uniquely engineered to provide balanced GIP and GLP-1 receptor engagement, yielding complementary metabolic effects:
GIP Receptor Agonism: Enhances glucose-dependent insulin secretion, promotes adipose tissue lipid storage, regulates adipokine secretion, and potentiates central appetite suppression.
GLP-1 Receptor Agonism: Suppresses glucagon release, further supports insulin secretion, slows gastric emptying, and centrally regulates hunger and satiety.
Pharmacokinetic Optimization: The addition of a C20 fatty diacid chain enables high-affinity albumin binding, significantly extending the terminal half-life to allow for a prolonged, once-weekly circulating depot.
Primary Research Applications
Tirzepatide is a crucial compound for in vitro and animal model studies investigating:
Superior Glycemic Control and Beta-Cell Function
Advanced Adipose Tissue Reduction and Weight Management
Cardiometabolic Benefits (including heart failure with preserved ejection fraction / HFpEF)
Non-Alcoholic Fatty Liver Disease (NAFLD) and Hepatic Fat Reduction
Metabolic factors underlying Obstructive Sleep Apnea
Storage & Handling
For optimal stability and structural integrity, store unopened vials at 36°F to 46°F (2°C to 8°C). If necessary, it may be stored at controlled room temperature for up to 21 days. Protect strictly from light.
⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. Tirzepatide is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.