Retatrutide (Triple Agonist) – LY3437943

At a Glance

Retatrutide is a next-generation peptide for weight loss, appetite control, and metabolic health. It works by targeting multiple hormone receptors involved in hunger regulation, blood sugar control, and energy expenditure, potentially leading to significant reductions in body weight and improvements in metabolic function.

Product Overview

Retatrutide is a first-in-class, next-generation triple hormone receptor agonist. Uniquely engineered to simultaneously target GLP-1, GIP, and glucagon receptors, this 39-amino acid modified peptide represents the forefront of metabolic research. By combining multiple pathways into a single molecule, it is designed for advanced study into profound energy expenditure, hepatic lipid metabolism, and appetite regulation.

Technical Specifications

• Molecular Formula: C221H342N46O68

• Molecular Weight: 4925.64 g/mol

• CAS Number: 2381089-83-2

• Sequence Profile: Modified 39 amino acid peptide featuring GLP-1, GIP, and glucagon receptor binding domains

Mechanism of Action

Retatrutide simultaneously activates three distinct G-protein coupled receptors involved in metabolic regulation:

• GLP-1 Receptor Agonism: Enhances glucose-dependent insulin secretion, delays gastric emptying, and suppresses appetite through hypothalamic pathways.

• GIP Receptor Agonism: Augments complementary insulin secretion and adipose effects.

• Glucagon Receptor Agonism: Uniquely promotes lipolysis (fat breakdown), amino acid catabolism, and thermogenesis (energy expenditure) to address both sides of the energy balance equation.

Primary Research Applications

Retatrutide is a vital compound for in vitro and animal model studies focusing on:

• Advanced Obesity and Weight Management Outcomes

• Type 2 Diabetes and Glycemic Control

• Non-Alcoholic Fatty Liver Disease (NAFLD) and NASH/MASH Pathways

• Metabolic Syndrome and Cardiovascular Risk Factor Reduction

Storage & Handling

For optimal stability and structural integrity, store at 36°F to 46°F (2°C to 8°C) and strictly protect from light.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. Retatrutide is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.