IGF-1 LR3 (Insulin-Like Growth Factor-1 Analog) – Long R3 IGF-1

Product Overview

IGF-1 LR3 is a highly potent, 83-amino acid synthetic analog of human Insulin-Like Growth Factor-1 (IGF-1). Engineered with precise structural modifications to effectively evade sequestration by IGF-binding proteins (IGFBPs), this compound demonstrates approximately three-fold greater biological potency than native IGF-1. By establishing an extended duration of receptor activation, IGF-1 LR3 is a premier compound utilized in advanced research focusing on massive skeletal muscle hypertrophy, dual-action cellular anabolism, and profound tissue regeneration.

Technical Specifications

• Molecular Formula: C400H625N111O115S9

• Molecular Weight: 9,111 g/mol

• CAS Number: 946870-92-4

• Sequence Profile: 83-amino acid synthetic peptide featuring an arginine substitution at position 3 (replacing glutamic acid) and a 13-amino acid N-terminal extension.

Mechanism of Action

IGF-1 LR3 achieves its profound hypertrophic and hyperplastic effects through critical signaling cascades and structural resistance:

• IGFBP Resistance: The Arg3 substitution and N-terminal extension reduce binding affinity to IGF-binding proteins by approximately 100-fold, allowing a significantly larger fraction of the peptide to remain free and bioactive in the extracellular space.

• PI3K/Akt/mTORC1 Pathway (Synthesis): Activates the IGF-1 receptor (IGF-1R) tyrosine kinase, leading to the phosphorylation of p70S6K and the inhibition of 4E-BP1, aggressively driving ribosomal protein synthesis and muscle hypertrophy.

• PI3K/Akt/FOXO1 Pathway (Anti-Degradation): Phosphorylates FOXO1, preventing its nuclear entry and the subsequent transcription of ubiquitin ligases (MAFbx, MuRF1). This effectively suppresses proteasomal protein degradation, establishing a net anabolic cellular environment.

• Satellite Cell Activation: Recruits quiescent satellite stem cells into the cell cycle, promoting myoblast proliferation and differentiation to contribute additional myonuclei to growing muscle fibers.

Primary Research Applications

IGF-1 LR3 is an indispensable compound for in vitro and animal model studies investigating:

• Skeletal Muscle Hypertrophy and Net Protein Synthesis

• Muscle Wasting Disease Models (Sarcopenia, Cachexia, Muscular Dystrophy)

• Cell Cycle Progression and Satellite Cell Mitogenic Responses

• Anti-Apoptotic Activity and Ischemia-Reperfusion Survival

• Connective Tissue and Tendon Repair Acceleration

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F to -112°F (-20°C to -80°C). Reconstituted solutions should be kept refrigerated at 39°F (4°C) and utilized within 1 month. Avoid repeated freeze-thaw cycles, and consider adding a carrier protein (e.g., 0.1% BSA) to dilute solutions to prevent adsorption loss.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. IGF-1 LR3 is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.