Ipamorelin (Selective Growth Hormone Secretagogue) – NNC 26-0161

Product Overview

Ipamorelin is an advanced, synthetic pentapeptide recognized as the first truly selective growth hormone secretagogue (GHRP). Engineered to act as a highly specific agonist at the ghrelin receptor (GHSR-1a), it stimulates a robust, pulsatile release of endogenous growth hormone from the pituitary gland. Unlike earlier generations of GHRPs, Ipamorelin provides a uniquely "clean" release profile, elevating growth hormone without meaningfully raising off-target stress hormones like cortisol, prolactin, or ACTH, making it an exceptional tool for isolated endocrinology and metabolic research.

Technical Specifications

• Molecular Formula: C38H49N9O5

• Molecular Weight: 711.85 g/mol

• CAS Number: 170851-70-4

• Sequence Profile: Aib-His-D-2-Nal-D-Phe-Lys-NH2

Mechanism of Action

Ipamorelin exerts its highly targeted effects by mimicking the natural hormone ghrelin, but with superior selectivity:

• GHSR-1a Activation: Binds directly to the growth hormone secretagogue receptor in the pituitary gland, triggering intracellular calcium release and GH granule exocytosis.

• Pulsatile Mimicry: Rather than forcing an unnatural, continuous elevation of GH that causes rapid receptor desensitization, Ipamorelin creates a discrete GH pulse that mimics the amplitude and duration of natural, endogenous secretory episodes, preserving vital feedback loop regulation.

• The Selectivity Advantage: It completely avoids the catabolic and immunosuppressive side effects associated with cortisol elevation, the gynecomastia concerns linked to prolactin, and the intense appetite-stimulating (ghrelin-mimetic) surges seen with compounds like GHRP-6.

Primary Research Applications

Ipamorelin is a premier compound for in vitro and animal model studies investigating:

• Selective Pituitary Growth Hormone Secretion Dynamics

• Body Composition, Lipolysis, and Skeletal Muscle Protein Synthesis

• Bone Density Preservation and Steroid-Induced Osteoporosis Models

• Sleep Architecture and Nocturnal GH Surge Synchronization

• Peptide Synergism (Frequently researched in combination with GHRH analogs like CJC-1295 for amplified, supra-additive GH release)

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized peptide securely at -4°F (-20°C). Reconstituted solutions should be kept refrigerated at 36°F to 46°F (2°C to 8°C) and protected from light.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. Ipamorelin is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.