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KISSPEPTIN

Kisspeptin (Kisspeptin-10) – Metastin Fragment

At a Glance: Kisspeptin, most commonly synthesized for research as the active fragment Kisspeptin-10, is a potent neuropeptide that serves as the primary upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. What it is used for: It is utilized in advanced laboratory research to study reproductive biology, hormone cascade initiation, and the restoration of natural testosterone or estrogen production. In lab rat models, researchers use it to observe how directly stimulating the HPG axis can reverse hypogonadism or jumpstart fertility pathways.

Product Overview

Kisspeptin (originally named Metastin) is a fundamental biological trigger responsible for initiating the hormone cascade that dictates puberty and reproductive function in mammals. As a highly targeted research peptide, Kisspeptin-10 is the shortest active sequence required to bind to the specific kisspeptin receptor. It represents a vital compound for studying the neuroendocrine system, allowing researchers to observe how stimulating the very top of the reproductive hormone chain can drive downstream endocrine function independent of direct steroid administration.

Technical Specifications

  • Molecular Formula: C63H83N17O14

  • Molecular Weight: 1302.4 g/mol

  • CAS Number: 374675-21-5

  • Sequence Profile: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (10-amino acid sequence with C-terminal amidation)

Mechanism of Action

Kisspeptin initiates its biological effects by acting directly on the hypothalamus at the apex of the neuroendocrine axis:

  • KISS1R Activation: Strongly binds to and activates the G-protein coupled receptor KISS1R (formerly known as GPR54) located on gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus.

  • GnRH Secretion: The activation of these neurons triggers a powerful, pulsatile release of GnRH into the hypophyseal portal system.

  • Downstream Hormone Cascade: The surge of GnRH subsequently signals the anterior pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which then travel to the gonads to stimulate the natural production of sex hormones (testosterone or estradiol) and gametogenesis.

Primary Research Applications

Kisspeptin is a vital compound for in vitro and animal model studies focusing on:

  • Hypothalamic-pituitary-gonadal (HPG) axis regulation and feedback loops

  • Hypogonadotropic hypogonadism and central reproductive suppression

  • The intersection of metabolism, energy balance, and fertility

  • Endogenous testosterone/estrogen production and spermatogenesis pathways

Storage & Handling

For optimal stability and structural integrity, store the lyophilized powder at -4°F (-20°C). Once reconstituted, store at 36°F to 46°F (2°C to 8°C), sealed tightly, and strictly protect from moisture and light.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. Kisspeptin is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.