KPV (Anti-Inflammatory Tripeptide)

Product Overview

KPV is a highly stable, naturally occurring tripeptide (Lys-Pro-Val) derived from the C-terminus of alpha-melanocyte-stimulating hormone (α-MSH). Uniquely designed to retain potent anti-inflammatory properties without activating melanocortin receptors, it completely lacks the pigmentation and appetite-modulating effects associated with its parent hormone. This makes KPV an exceptional research compound for investigating profound, receptor-independent immunomodulation and localized tissue repair.

Technical Specifications

• Molecular Formula: C16H30N4O4

• Molecular Weight: 342.44 g/mol

• CAS Number: 67727-97-3

• Sequence Profile: Lys-Pro-Val (C-terminal tripeptide fragment of α-MSH)

Mechanism of Action

KPV exerts its regulatory effects through unique, receptor-independent intracellular pathways that directly suppress inflammatory cascades:

• NF-κB Inhibition: The tripeptide directly enters cells to block the nuclear translocation of NF-κB (the master inflammatory transcription factor), effectively downregulating the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6.

• Inflammasome Modulation: Suppresses NLRP3 inflammasome activation, limiting damaging immune cell hyper-responses while preserving vital antimicrobial defense mechanisms.

• Antimicrobial Properties: Demonstrates direct antimicrobial and fungicidal activity independent of its immune-modulating effects, particularly useful in models of infected wounds or microbiome dysbiosis.

• Gastrointestinal Stability: Exhibits a rare structural resilience that allows it to maintain biological activity in the digestive tract, facilitating unique oral/localized delivery research.

Primary Research Applications

KPV is a premier compound for in vitro and animal model studies investigating:

• Inflammatory Bowel Disease (IBD) and Colonic Mucosal Healing

• Advanced Wound Healing, Keratinocyte Migration, and Scar Reduction

• Dermatological Autoimmunity (Psoriasis, Atopic Dermatitis)

• Systemic Anti-Inflammatory Applications Without Corticosteroid-like Immunosuppression

• Neuroinflammation and Blood-Brain Barrier (BBB) Penetration

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C). Reconstituted solutions should be kept refrigerated at 36°F to 46°F (2°C to 8°C) for short-term use.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. KPV is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.