Mazdutide (Dual Glucagon/GLP-1 Receptor Agonist) – IBI362

Product Overview

Mazdutide is an innovative, once-weekly dual agonist peptide engineered to mimic and enhance the biological activity of oxyntomodulin, an endogenous intestinal hormone. By simultaneously activating both the Glucagon-like Peptide-1 (GLP-1) receptor and the Glucagon receptor (GCGR), Mazdutide offers a multifaceted approach to metabolic regulation. This dual-agonism strategy is designed to drive potent appetite suppression via the GLP-1 receptor, while the glucagon receptor component actively increases total energy expenditure and optimizes hepatic lipid metabolism. It is a premier compound utilized in advanced research for weight management, metabolic homeostasis, and the treatment of metabolic dysfunction-associated steatohepatitis (MASH).

Technical Specifications

• Molecular Formula: C207H317N45O65

• Molecular Weight: 4563.06 g/mol

• CAS Number: 2259884-03-0

• Receptor Profile: Balanced Dual Agonist (Glucagon Receptor + GLP-1 Receptor)

Mechanism of Action

Mazdutide employs a sophisticated, synergistic mechanism to restore metabolic balance:

• GLP-1 Receptor Agonism: Stimulates glucose-dependent insulin secretion, suppresses glucagon release, and activates central hypothalamic satiety centers to induce sustained appetite reduction and caloric restriction.

• Glucagon Receptor Agonism (GCGR): Direct activation of hepatic glucagon receptors promotes lipid oxidation, glycogenolysis, and thermogenesis. This elevates the basal metabolic rate and provides a direct, pharmacologic mechanism to mobilize and clear hepatic fat (steatosis).

• Metabolic Reprogramming: Enhances amino acid catabolism, promotes ketogenesis, and stimulates fibroblast growth factor 21 (FGF21) secretion, collectively facilitating a profound shift in whole-body substrate utilization.

• Balanced Homeostasis: The optimized ratio of GLP-1/GCGR activity ensures that the potential hyperglycemic effects of glucagon are effectively neutralized by the insulinotropic and metabolic-suppressive effects of GLP-1, resulting in net improvements in both glycemic control and body composition.

🚚 📦 Availability 

At CNL, we believe quality is worth the wait. Instead of stocking products and have them sit for months, most orders are produced in small batches to maintain the quality and consistency our customers expect.

Production typically takes approximately two weeks. While this isn't the norm in today's world of overnight delivery, it's how we deliver the premium quality we're known for.

Limited inventory may be available for immediate shipment after large production runs or special promotions.

As a thank you for your patience, we offer bundle discounts of up to 50% OFF.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. Mazdutide is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.