Melanotan II (Pan-Melanocortin Receptor Agonist) – MT-II

Product Overview

Melanotan II is a highly potent, synthetic cyclic lactam analog of alpha-melanocyte stimulating hormone (α-MSH). As a non-selective pan-melanocortin agonist, it simultaneously targets multiple receptor subtypes (MC1R through MC5R), producing a diverse array of physiological responses. Originally developed at the University of Arizona, Melanotan II is a foundational research compound utilized for advanced studies investigating UV-independent skin pigmentation, the central nervous system's regulation of sexual function, and the neuroendocrine control of appetite and energy homeostasis.

Technical Specifications

• Molecular Formula: C50H69N15O9

• Molecular Weight: 1024.18 g/mol

• CAS Number: 121062-08-6

• Sequence Profile: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH2 (Cyclic structure engineered for potent melanocortin receptor activation)

Mechanism of Action

Melanotan II exerts broad biological effects due to its unique lack of receptor selectivity, activating multiple pathways simultaneously:

• MC1R Activation (Melanogenesis): Binds directly to melanocortin-1 receptors on melanocytes, triggering the cAMP-PKA-CREB signaling cascade. This upregulates the MITF transcription factor to stimulate the production of eumelanin (dark pigment), resulting in progressive skin darkening even without UV exposure.

• MC3R & MC4R Activation (Sexual Function): Crosses into the central nervous system to activate receptors in the hypothalamic nuclei, modulating dopamine signaling and oxytocinergic pathways linked to sexual arousal and behavior.

• MC4R Activation (Appetite Modulation): Modulates neuropeptide Y (NPY) and agouti-related peptide (AgRP) neurons in the arcuate nucleus, shifting the central melanocortin-leptin signaling axis toward reduced hunger signals and suppressed caloric intake.

• Peripheral Fat Metabolism: Increases sympathetic nervous system activity to adipose tissues via MC4R, promoting enhanced beta-adrenergic signaling and fatty acid oxidation.

Primary Research Applications

Melanotan II is a premier compound for in vitro and animal model studies investigating:

• UV-Independent Melanogenesis, Photoprotection, and Skin Pigmentation

• Neurobiological Pathways of Libido Enhancement and Sexual Motivation

• Appetite Suppression, Anorectic Signaling, and Energy Balance

• Lipolysis, Thermogenesis, and Visceral Adipose Tissue Reduction

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C) and strictly protect from light. Reconstituted solutions should be kept refrigerated at 36°F to 46°F (2°C to 8°C).

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. Melanotan II is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research