MOTS-c (Mitochondrial-Derived Peptide) – Exercise Mimetic

Product Overview

MOTS-c is a breakthrough 16-amino acid peptide that represents a new class of "mitokines"—signaling molecules encoded directly within the mitochondrial genome rather than nuclear DNA. Discovered as a master regulator of metabolic homeostasis, it possesses the unique ability to translocate from the mitochondria to the cell nucleus, where it directly reprograms gene expression to optimize metabolic adaptation. Often termed an "exercise mimetic," MOTS-c is utilized in cutting-edge research to investigate insulin sensitivity, fatty acid oxidation, and the fundamental link between mitochondrial bioenergetics and healthy aging.

Technical Specifications

• Molecular Formula: C101H152N28O22S2

• Molecular Weight: 2174.59 g/mol

• CAS Number: 1627580-64-6

• Sequence Profile: MRWQEMGYIFYPRKLR (Encodes the bioactive region derived from the 12S rRNA gene)

Mechanism of Action

MOTS-c modulates systemic metabolism through innovative retrograde mitochondria-to-nucleus communication pathways:

• AMPK Activation (The Master Energy Sensor): Potently activates AMP-activated protein kinase (AMPK) by inhibiting the folate-methionine cycle, which causes an accumulation of endogenous AICAR. This triggers a cascading metabolic shift toward glucose uptake, increased fatty acid oxidation, and improved mitochondrial efficiency.

• Nuclear Gene Reprogramming: Translocates from the mitochondria to the nucleus under metabolic stress, where it directly modulates the expression of genes involved in cellular stress response, metabolic adaptation, and long-term bioenergetic resilience.

• Insulin Sensitivity Optimization: Facilitates GLUT4 translocation in skeletal muscle, effectively mimicking the metabolic shifts that occur during physical exercise to lower blood glucose and enhance insulin sensitivity without the need for high-intensity exertion.

• Thermogenic & Adipose Modulation: Promotes the "browning" of white adipose tissue, effectively converting energy-storing fat into metabolically active tissue that consumes energy via thermogenesis.

Primary Research Applications

MOTS-c is a premier compound for in vitro and animal model studies investigating:

• Metabolic Homeostasis and Insulin Resistance (Type 2 Diabetes Models)

• Exercise Mimetics, Endurance Capacity, and Mitochondrial Biogenesis

• Obesity Resistance and Diet-Induced Adipose Tissue Accumulation

• Age-Related Metabolic Decline and Longevity Research

• Retrograde Mitochondrial-to-Nuclear Signaling Pathways

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C). Reconstituted solutions should be kept refrigerated at 36°F to 46°F (2°C to 8°C) and utilized according to laboratory-specific protocols, avoiding any repeated freeze-thaw cycles.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. MOTS-c is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.