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NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) – Oxidized Coenzyme

At a Glance: NAD+ is a fundamental, naturally occurring coenzyme found in all living cells, essential for cellular metabolism and energy production. What it is used for: It is utilized in advanced laboratory research to study cellular senescence, mitochondrial dysfunction, and DNA repair. In lab rat models, researchers study its ability to rapidly restore cellular energy (ATP) levels, activate longevity pathways, and combat age-related metabolic decline.

Product Overview

NAD+ is the absolute cornerstone of cellular respiration and energy transfer. While its natural synthesis rapidly declines with age, exogenous NAD+ administration in research settings allows for the direct replenishment of cellular reservoirs. Beyond merely serving as an energy conduit, it acts as a critical, consumable substrate for sirtuins (proteins that regulate cellular health and aging) and PARPs (enzymes that facilitate DNA repair). It represents a vital compound for studying how restoring youthful energy metabolism can reverse systemic aging, repair genetic damage, and fortify the central nervous system against neurodegenerative stress in research subjects.

Technical Specifications

  • Molecular Formula: C21H27N7O14P2

  • Molecular Weight: 663.43 g/mol

  • CAS Number: 53-84-9

  • Chemical Profile: Oxidized dinucleotide containing an adenine base and a nicotinamide base joined by a pair of phosphate groups.

Mechanism of Action

NAD+ initiates profound systemic effects by functioning as both a universal electron transporter and a crucial signaling molecule:

  • Mitochondrial ATP Production (Redox Reactions): Acts as the primary electron carrier in metabolic processes, capturing electrons from nutrients and delivering them to the electron transport chain to generate massive amounts of ATP (cellular energy).

  • Sirtuin Activation: Serves as the essential, rate-limiting fuel for sirtuins (SIRT1-7). When activated by NAD+, these epigenetic regulators go to work silencing aging genes, reducing systemic inflammation, and triggering mitochondrial biogenesis (the creation of new, healthy mitochondria).

  • DNA Repair (PARP Substrate): It is actively consumed by Poly (ADP-ribose) polymerases (PARPs) to quickly detect and repair single-strand DNA breaks, preventing genomic instability caused by daily oxidative stress, toxins, or radiation.

Primary Research Applications

NAD+ is a vital compound for in vitro and animal model studies focusing on:

  • Anti-aging, cellular senescence, and lifespan extension pathways

  • Neurodegenerative disease models and cognitive decline

  • Mitochondrial dysfunction, chronic fatigue, and energy homeostasis

  • Metabolic syndrome and cellular recovery from addiction or substance withdrawal

Storage & Handling

For optimal stability and structural integrity, store the lyophilized powder at -4°F (-20°C). Once reconstituted, store at 36°F to 46°F (2°C to 8°C), sealed tightly, and strictly protect from moisture and light. NAD+ in solution is particularly sensitive to rapid degradation if exposed to ambient heat or prolonged UV light.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. NAD+ is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.