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OXYTOCIN

Oxytocin – Neurohypophysial Nonapeptide

At a Glance: Oxytocin is a highly conserved, naturally occurring nonapeptide (nine-amino-acid peptide) produced in the hypothalamus that functions as both a hormone and a powerful central neurotransmitter.What it is used for: It is utilized in advanced laboratory research to study the neurobiology of social behavior, trust, emotional regulation, and maternal-infant bonding. Researchers also frequently use it to investigate neurological pathways related to autism spectrum disorder (ASD), anxiety, and stress modulation.

Product Overview

Oxytocin is a potent neuropeptide fundamentally tied to mammalian reproduction, social bonding, and behavioral regulation. While historically known for its peripheral roles in parturition and lactation, modern metabolic and neurological research heavily focuses on its profound central nervous system (CNS) effects. By interacting directly with reward and fear-processing centers in the brain, oxytocin represents a crucial compound for studying neuroplasticity, social cognition, and psychopharmacological interventions for stress-related disorders.

Technical Specifications

  • Molecular Formula: C43H66N12O12S2

  • Molecular Weight: 1007.19 g/mol

  • CAS Number: 50-56-6

  • Sequence Profile: Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Cyclic peptide featuring a distinct Cys1-Cys6 disulfide bridge and C-terminal amidation)

Mechanism of Action

Oxytocin exerts its biological and behavioral effects by binding to the specific Oxytocin Receptor (OXTR), a G-protein coupled receptor:

  • Central Neuromodulation: Acts directly on receptors in the amygdala, hippocampus, and nucleus accumbens. It dampens amygdala hyperactivity (reducing fear and anxiety responses) while modulating dopamine pathways to enhance prosocial behaviors and trust.

  • HPA Axis Regulation: Interacts with the hypothalamic-pituitary-adrenal (HPA) axis to attenuate the release of cortisol, effectively acting as an endogenous buffer against physiological stress.

  • Peripheral Activation: In peripheral tissues, OXTR binding triggers an influx of intracellular calcium, leading to the contraction of specific smooth muscle tissues (such as myoepithelial and uterine cells).

Primary Research Applications

Oxytocin is a vital compound for in vitro and animal model studies focusing on:

  • Neurodevelopmental disorder models, particularly Autism Spectrum Disorder (ASD)

  • Social cognition, pair-bonding, and maternal behavioral neurobiology

  • Fear extinction, anxiety modulation, and trauma research

  • Pain perception (analgesia) and substance withdrawal/addiction pathways

Storage & Handling

For optimal stability and structural integrity—particularly to preserve the fragile disulfide bridge—store at 36°F to 46°F (2°C to 8°C) and strictly protect from light.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. Oxytocin is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.