Selank (Cognitive Enhancement Peptide) – TP-7

Product Overview

Selank is an advanced synthetic heptapeptide created by conjugating a Pro-Gly-Pro extension to the endogenous immunomodulatory tetrapeptide tuftsin. Originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it represents a significant breakthrough in neuropharmacological research. Selank is uniquely characterized by its ability to provide potent anxiolytic effects without the sedation, cognitive impairment, or tolerance typical of traditional GABA-enhancing compounds, making it an invaluable tool for studying the intersection of stress response, immune function, and cognitive performance.

Technical Specifications

• Molecular Formula: C33H57N11O9

• Molecular Weight: 751.87 g/mol

• CAS Number: 129954-34-3

• Sequence Profile: Thr-Lys-Pro-Arg-Pro-Gly-Pro (tuftsin extended with a Pro-Gly-Pro tripeptide sequence for plasma stability and enhanced CNS penetration)

Mechanism of Action

Selank exhibits a unique dual-timescale pharmacology, producing immediate neurochemical shifts combined with sustained gene expression alterations:

• GABAergic and Enkephalin System Modulation (Acute): Rapidly influences GABA-A receptor sensitivity and inhibits enkephalin-degrading enzymes, increasing endogenous enkephalin levels for potent, non-sedating anxiolysis.

• Neurotrophin Upregulation (Sustained): Stimulates the expression of Brain-Derived Neurotrophic Factor (BDNF), Nerve Growth Factor (NGF), and neurotrophin-3, enhancing hippocampal synaptic plasticity and long-term potentiation (LTP).

• Immunomodulation: Retains the receptor activity of its parent molecule, tuftsin, modulating over 50 inflammation-related genes, enhancing phagocytic activity, and balancing pro-inflammatory/anti-inflammatory cytokine ratios (such as IL-6).

• HPA Axis Regulation: Mitigates stress-induced spikes in cortisol/corticosterone while preserving serotonin and dopamine turnover in stress-processing brain regions.

Primary Research Applications

Selank is a premier compound for in vitro and animal model studies investigating:

• Non-Sedating Anxiolysis and Generalized Anxiety/Panic Disorders

• Cognitive Enhancement, Memory Consolidation, and Sustained Attention

• Stress Adaptation, HPA Axis Normalization, and PTSD Models

• Neuroprotection and BDNF/Synaptic Plasticity Upregulation

• Peptide-based Immunomodulation and Tuftsin-Receptor Pathways

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C). Reconstituted solutions should be strictly refrigerated at 36°F to 46°F (2°C to 8°C) to preserve the peptide sequence.

⚠️ Important Disclaimer for Carbon Nova Labs Customers:

All information provided is for educational and reference purposes only. Selank is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.