Semax (Cognitive Enhancement Peptide) – ACTH 4-10 Analog

Product Overview

Semax is a highly advanced synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) 4-10 fragment. Originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it has been precisely engineered to retain potent cognitive-enhancing and neuroprotective properties while completely eliminating the steroidogenic activity of its parent hormone. Unlike traditional stimulants, Semax is utilized in cutting-edge research to observe cumulative enhancements in neuroplasticity, memory formation, and profound brain-derived neurotrophic factor (BDNF) upregulation.

Technical Specifications

• Molecular Formula: C37H51N9O10S

• Molecular Weight: 813.93 g/mol

• CAS Number: 80714-61-0

• Sequence Profile: Met-Glu-His-Phe-Pro-Gly-Pro (ACTH analog engineered with a C-terminal Pro-Gly-Pro extension for proteolytic stability)

Mechanism of Action

Semax exerts its remarkable neurocognitive effects through multiple interconnected pathways rather than acute neurotransmitter flooding:

• Dual Neurotrophic Modulation: Simultaneously and significantly upregulates the expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in regions like the hippocampus and prefrontal cortex, driving synaptic plasticity and neurogenesis.

• Dopaminergic and Serotonergic Activation: Enhances dopamine release (affecting motivation and focus) and serotonin turnover (affecting mood and memory consolidation) to improve executive function.

• Proteolytic Stability Engineering: The addition of a Pro-Gly-Pro extension inhibits rapid enkephalinase cleavage. While plasma clearance remains rapid, this engineering allows it to trigger sustained transcriptional programs and neurotrophic effects that persist for hours or days after administration.

Primary Research Applications

Semax is a premier compound for in vitro and animal model studies investigating:

• Advanced Cognitive Enhancement, Working Memory, and Information Processing Speed

• Neuroprotection Against Ischemia, Hypoxia, and Oxidative Stress

• Brain Injury Rehabilitation and Neurorestorative Plasticity

• Non-Sedating Anxiolytic Effects and Stress-Related Cognitive Impairment

• Central Nervous System (CNS) Penetration and Intranasal Delivery Dynamics

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C). Reconstituted solutions or spray formulations should be kept refrigerated at 36°F to 46°F (2°C to 8°C).

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. Semax is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.