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SLU-PP-332

SLU-PP-332 (Commonly listed as SLU-PP-322) – Pan-ERR Agonist

At a Glance: SLU-PP-332 (frequently listed across the industry under the typo SLU-PP-322) is a synthetic, non-steroidal small molecule that functions as a potent pan-agonist for estrogen-related receptors (ERRs). Note: While it is usually grouped with peptides in research catalogs, it is structurally a chemical small molecule. What it is used for: It is utilized in laboratory research as a novel "exercise mimetic." In lab rat models, it is studied for its unique ability to trigger the exact metabolic pathways associated with intense aerobic exercise—such as increased fat oxidation and mitochondrial biogenesis—without actual physical exertion.

Product Overview

SLU-PP-332 is a cutting-edge research compound designed to mimic the physiological benefits of physical training directly at the cellular level. By targeting the estrogen-related orphan receptors (ERRs) that regulate systemic energy expenditure, this molecule forces the subject into an amplified aerobic metabolic state. It represents a significant breakthrough for studying metabolic syndrome, allowing researchers to observe how activating exercise-specific genetic pathways can drive profound body fat metabolism and energy utilization in lab rats independent of mechanical stimulus, diet changes, or appetite suppression.

Technical Specifications

  • Molecular Formula: C18H14N2O2

  • Molecular Weight: 290.32 g/mol

  • CAS Number: 303760-60-3

  • Chemical Profile: (E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide (Synthetic Small Molecule)

Mechanism of Action

SLU-PP-332 initiates its biological effects by activating cellular energy pathways rather than central nervous system stimulation:

  • Pan-ERR Agonism: Strongly binds to and activates all three estrogen-related receptors (ERRα, ERRβ, and ERRγ). Despite their historical naming, these receptors do not bind estrogen; they are primary metabolic regulators found heavily in energy-demanding tissues like skeletal muscle, the kidneys, and the heart.

  • Mitochondrial Biogenesis: Upregulates target genes (such as Pdk4) responsible for creating new mitochondria. This effectively increases the overall oxidative capacity and cellular respiration of the muscle tissue.

  • Metabolic Shifting (Exercise Mimicry): By activating these pathways, it shifts the animal's metabolism to preferentially oxidize (burn) circulating fatty acids for energy rather than carbohydrates, perfectly replicating the internal metabolic environment of a lab rat undergoing intense, sustained endurance training.

Primary Research Applications

SLU-PP-332 is a vital compound for in vitro and animal model studies focusing on:

  • Exercise mimetics and aerobic endurance enhancement

  • Diet-induced obesity and metabolic syndrome reversal

  • Type 2 Diabetes and insulin sensitivity

  • Age-related mitochondrial dysfunction and muscle preservation

Storage & Handling

For optimal stability and structural integrity, store the solid powder at -4°F (-20°C). Once reconstituted in a solvent (such as DMSO), store tightly sealed at 36°F to 46°F (2°C to 8°C) and strictly protect from moisture and light.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. SLU-PP-332 is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.