SNAP-8 (Anti-Aging Octapeptide) – Acetyl Octapeptide-3

Product Overview

SNAP-8 (Acetyl Octapeptide-3) is a highly specialized, synthetic octapeptide engineered as a next-generation extension of the hexapeptide Argireline. By incorporating two additional amino acids, SNAP-8 achieves superior molecular stability and significantly increased binding affinity to its biological targets. It is a premier compound utilized in advanced cosmetic and dermatological research to investigate the non-invasive modulation of the SNARE complex, offering a targeted approach to reducing the depth and intensity of dynamic expression wrinkles.

Technical Specifications

• Molecular Formula: C41H70N16O16S

• Molecular Weight: 1075.16 g/mol

• CAS Number: 868844-74-0

• Sequence Profile: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Synthetic octapeptide engineered to mimic the N-terminal end of SNAP-25)

Mechanism of Action

SNAP-8 modulates the intensity of neuromuscular signals through precise, competitive molecular mimicry:

• SNARE Complex Inhibition: Competitively inhibits the formation of the SNARE complex—the essential machinery required for the fusion of neurotransmitter vesicles to the membrane. By mimicking the N-terminal domain of the SNAP-25 protein, SNAP-8 effectively occupies binding sites, reducing the efficiency of acetylcholine release at the neuromuscular junction.

• Neuromuscular Modulation: Diminishes the intensity of local muscle contractions that cause deep expression lines (such as forehead furrows, crow's feet, and perioral lines) without causing the systemic or complete paralysis associated with injectable neurotoxins.

• Dynamic Wrinkle Management: Specifically targets the repetitive, mechanical stress placed on skin collagen and elastin fibers by dynamic facial muscle movements, thereby preventing the progressive deepening of expression lines.

Primary Research Applications

SNAP-8 is a critical compound for in vitro and dermatological model studies investigating:

• Dynamic Expression Line Reduction and Skin Topography Optimization

• SNARE Complex Assembly Dynamics and Neuromuscular Junction Signaling

• Non-Invasive Anti-Aging Skincare Protocols

• Synergistic Peptide Stacking (e.g., combining with collagen-stimulating peptides for comprehensive rejuvenation)

• Transdermal Delivery and Bioavailability Optimization

Storage & Handling

For optimal long-term stability and structural integrity, store lyophilized powder securely at -4°F (-20°C), protected strictly from light. Reconstituted solutions or cosmetic formulations should be kept refrigerated at 36°F to 46°F (2°C to 8°C) and utilized within defined stability timelines to ensure the continued efficacy of the octapeptide sequence.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. SNAP-8 is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.