Survodutide (Dual Glucagon/GLP-1 Receptor Agonist) – BI 456906

Product Overview

Survodutide is a breakthrough, long-acting dual agonist peptide engineered to simultaneously activate the glucagon receptor (GCGR) and the glucagon-like peptide-1 (GLP-1) receptor. This dual-action mechanism is specifically designed to provide a synergistic metabolic effect: while the GLP-1 receptor component provides potent appetite suppression and insulin regulation, the glucagon receptor agonism directly increases total energy expenditure and promotes hepatic lipid oxidation. Survodutide represents a premier research compound for studying profound weight management, hepatic steatosis (MASH/NASH) reversal, and the optimization of metabolic homeostasis.

Technical Specifications

• Molecular Formula: C192H289N47O61

• Molecular Weight: 4231.63 g/mol

• CAS Number: 2805997-46-8

• Receptor Profile: Dual Agonist (Glucagon Receptor + GLP-1 Receptor)

Mechanism of Action

Survodutide engages two distinct physiological systems to deliver comprehensive metabolic control:

• GLP-1 Receptor Agonism: Stimulates glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and activates central hypothalamic satiety pathways to drastically reduce food intake.

• Glucagon Receptor Agonism (GCGR): Directly stimulates hepatic glycogenolysis and gluconeogenesis, increases total energy expenditure through thermogenic pathways (including brown adipose tissue activation), and actively promotes hepatic lipid oxidation.

• Direct Hepatic Efficacy: The inclusion of GCGR agonism provides a distinct mechanistic advantage over pure GLP-1 agonists; it directly targets the liver to reduce de novo lipogenesis and fat accumulation, potentially improving fibrosis and steatosis independently of total weight loss.

• Glycemic Homeostasis: The optimized ratio of GLP-1/GCGR activity ensures that the potential hyperglycemic effects of glucagon are fully offset by the insulinotropic effects of GLP-1, resulting in a net improvement in glucose tolerance.

🚚 📦 Availability 

At CNL, we believe quality is worth the wait. Instead of stocking products and have them sit for months, most orders are produced in small batches to maintain the quality and consistency our customers expect.

Production typically takes approximately two weeks. While this isn't the norm in today's world of overnight delivery, it's how we deliver the premium quality we're known for.

Limited inventory may be available for immediate shipment after large production runs or special promotions.

As a thank you for your patience, we offer bundle discounts of up to 50% OFF.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. Survodutide is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.