Thymosin Alpha-1 (Immunomodulatory Peptide) – Tα1 / Thymalfasin

Product Overview

Thymosin Alpha-1 (Tα1) is a highly validated, 28-amino-acid peptide originally isolated from thymic tissue. Unlike most research peptides, Tα1 is a clinically recognized immunomodulator approved in over 35 countries for the treatment of chronic hepatitis B/C, immune deficiency states, and as a potent chemotherapy adjuvant. It is a premier compound for advanced research into T-cell maturation, the orchestration of Th1-polarized immune responses, and the activation of dendritic cell-mediated host defense mechanisms.

Technical Specifications

• Molecular Formula: C129H215N33O55

• Molecular Weight: 3108.3 g/mol

• CAS Number: 62304-98-7

• Sequence Profile: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn

Mechanism of Action

Thymosin Alpha-1 functions as a broad-spectrum immune orchestrator rather than a simple stimulant, acting through highly regulated intracellular pathways:

• Dendritic Cell Activation: Directly engages Toll-like receptors (TLR2 and TLR9), triggering MyD88-dependent NF-kB signaling. This enhances dendritic cell maturation, upregulates CD80/CD86/MHC-II expression, and optimizes antigen presentation for T-cell priming.

• T-Cell Maturation & Lineage Commitment: Promotes the differentiation of thymocyte precursors into mature, functional T-cell subsets (helper and cytotoxic), significantly increasing peripheral T-cell repertoire diversity and immunocompetence.

• Th1 Polarization: Shifts the immune balance toward a Th1-predominant profile by promoting the production of critical pro-inflammatory cytokines like IFN-gamma and IL-2, which are essential for robust antiviral and antitumor responses.

• Immune Tolerance Induction: Uniquely balances activation with tolerance by promoting regulatory T-cell (Treg) induction, thereby mitigating the risk of autoimmune overactivation—a distinction from conventional immunostimulants.

🚚 📦 Availability 

At CNL, we believe quality is worth the wait. Instead of stocking products and have them sit for months, most orders are produced in small batches to maintain the quality and consistency our customers expect.

Production typically takes approximately two weeks. While this isn't the norm in today's world of overnight delivery, it's how we deliver the premium quality we're known for.

Limited inventory may be available for immediate shipment after large production runs or special promotions.

As a thank you for your patience, we offer bundle discounts of up to 50% OFF.

⚠️ Important Disclaimer for Carbon Nova Labs Customers: All information provided is for educational and reference purposes only. Thymosin Alpha-1 is sold strictly for laboratory research use only. This compound is not approved by the FDA for human consumption, therapeutic use, or clinical application. Ensure compliance with all institutional safety protocols and consult qualified professionals before conducting research.